Anti-biofilm activity of quercetin and umbelliferone against some multi-drug resistant bacteria

Eda ALTINOZ1*, Ergin Murat ALTUNER1

1Kastamonu University, Faculty of Science and Arts, Department of Biology, TR 37100 Kastamonu, Turkey

* Corresponding author: altinozedaa@gmail.com

Microorganisms produce polysaccharide-based structures, which can be used to adhere to the surfaces to protect themselves. Due to the protective nature of these structures, microorganisms can produce immediate responses to the adverse effects in their environment. Therefore, microorganisms that protect themselves cannot be easily removed from the surface they attached and this can lead to resistance. As a result of this, problems are experienced mostly in dental treatments, medicine, the food industry, water systems, drug resistance, and sterilization processes. Various studies continue to be carried out to eliminate the formed biofilm or to prevent the formation of biofilm. This study aims to observe the in vitro anti-biofilm activity of quercetin and umbelliferone against some MDR strains. The bacteria used in the study are standard Esherichia coli ATCC 25922, three clinical isolate MDR E. coli strains, Acinetobacter baumannii (MDR), Klebsiella pneumoniae (MDR), MRSA, and Shigella flexneri (MDR). According to the results of the experiment, dose-dependent biofilm activation and inhibition effects were observed. Further studies are required to put forward the mechanism of action of quercetin and umbelliferone on bacterial biofilm formation.
Keywords:Biofilm, anti-biofilm, inhibition, MDR, quercetin, umbelliferone

How to cite: Altinoz, E., & Altuner, E.M. (2021, Nov 24-26). Anti-biofilm activity of quercetin and umbelliferone against some multi-drug resistant bacteria [Conference presentation]. p.1136. 4th International Eurasian Conference on Biological and Chemical Sciences, Ankara, Turkey.

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