Microorganisms produce polysaccharide-based structures, which can be used to adhere to the surfaces to protect themselves. Due to the protective nature of these structures, microorganisms can produce immediate responses to the adverse effects in their environment. Therefore, microorganisms that protect themselves cannot be easily removed from the surface they attached and this can lead to resistance. As a result of this, problems are experienced mostly in dental treatments, medicine, the food industry, water systems, drug resistance, and sterilization processes. Various studies continue to be carried out to eliminate the formed biofilm or to prevent the formation of biofilm. This study aims to observe the in vitro anti-biofilm activity of quercetin and umbelliferone against some MDR strains. The bacteria used in the study are standard Esherichia coli ATCC 25922, three clinical isolate MDR E. coli strains, Acinetobacter baumannii (MDR), Klebsiella pneumoniae (MDR), MRSA, and Shigella flexneri (MDR). According to the results of the experiment, dose-dependent biofilm activation and inhibition effects were observed. Further studies are required to put forward the mechanism of action of quercetin and umbelliferone on bacterial biofilm formation.
Altinoz, E., Altuner, E.M. (2020). Responses of some Escherichia coli clinical isolate strains with multiple drug resistance and overexpressed efflux pumps against efflux pump inhibitors. International Journal of Biology and Chemistry, 13(1): 77-87.
Altinoz, E. (2019). Çoklu İlaç Direnci Gösteren Ve Efflux Pompa Sistemi Çalışan Escherichia Coli Suşlarının Efflux Pompası İnhibitörlerine Karşı Cevaplarının Gözlenmesi. (Yüksek Lisans Tezi, Kastamonu Üniversitesi).
Altınoz, E., Altuner, E.M. (2019). Antibiotic resistance and efflux pumps. International Journal of Innovative Research and Reviews, 3(2): 1-9.